Famed throughout Asia for its heady mix of eastern cultures, Penang Island is Malaysia’s prime melting pot. Roadside vendors serve some of the world’s best street food; its national parks offer white-sand beaches and wildlife; and UNESCO-listed George Town is full of colorful heritage houses.

The British colonial city of Ipoh had humble beginnings, but has blossomed into a beautiful cityscape that marries old-world charm with modern amenities. This is a foodie's city, offering endless street stalls and restaurants all eager to serve up a sample of mouthwatering local fare. Walk it all off on a jaunt through breathtaking limestone caves that seem carved by the capable hands of a higher power.

The cultural hub of Malaysia, Kuala Lumpur is visually defined by the iconic Petronas Twin Towers, which, at 88 stories high, are the tallest twin buildings in the world and a vision of modern architecture. On the flip side, the Sri Mahamariamman is the oldest Hindu temple in Malaysia, its façade a colorful totem pole of iconography. Shopping at the Central Market is a joyful experience that involves haggling, handicrafts, and happiness.

This charming city is a UNESCO world heritage site, with a rich trading history and multicultural heritage. Melaka is a rewarding town to explore and is about two hours from Kuala Lumpur.

Johor Bahru is the second-largest city in Malaysia and, with the opening of two major amusement parks in 2012, it is poised to become a major tourist destination. TripAdvisor travellers also recommend visiting the Arulmigu Sri Rajakaliamman Glass Temple, a unique Hindu temple decorated with brilliant glass mosaics.

Bangkok is full of exquisitely decorated Buddhist temples—as you go from one to the next you’ll be continually blown away by the craftsmanship and elabourate details. But if you’d rather seek enlightenment in a gourmet meal, or dance the night away, you’ll also enjoy Bangkok—the restaurant and nightclub scenes here are among the best in the world.

Kuching is a fine choice for an enriching vacation that's as packed with learning as it is leisure. Its many museums and impressive planetarium will enthrall even the tiniest travelers, and a quick climb to the top of the Kuching Civic Center will reward you with jaw-dropping 360-degree views. Grab a snack from a stall on the bustling waterfront, and don't miss the absolutely massive Sunday market, which is an electric experience for shoppers, vendors, and observers.

Da Nang is laid-back and friendly, maybe because everyone you meet has just finished an amazing meal. Culinary tours are a hugely popular way to experience literal local flavor. After you’ve stuffed yourself with bold noodle soups and savory street foods, walk it off by exploring the limestone caves and Buddhist grottos of the Marble Mountains.

Chaotic, crowded, and cosmopolitan, Jakarta, the capital of Indonesia, is a city of contrasts. Home to millions of people from around the world, the city is a mixture of languages and cultures, poverty and wealth. The city boasts some of the best nightlife in Asia and some of the worst traffic. Every holiday, the locals escape the pollution and the crowds to enjoy relaxing diversions like Ancol Dreamland, an amusement area featuring water parks, beaches, golf courses, and a SeaWorld.

You could spend your whole Chiang Mai holiday exploring the famous Night Bazaar. Once you’ve exhausted the art of the cheerful haggle, however, there’s plenty more to explore. The National Museum and Botanic Garden are great places to soak up some local culture and to breathe in the delicate fragrance of Thai orchids. In the city’s centre, the remains of ancient walls embrace over 30 temples. Limber travellers can climb 300 stairs to Wat Phrathat Doi Suthep, an ornate Buddhist temple in the hills.

Kota Kinabalu on the island of Borneo is the bustling gateway to acclaimed Kinabalu National Park. The park's high point is 13,400-foot Mount Kinabula, Malaysia's tallest peak, a mecca for climbers. Ninety miles away, thrilling jungle trekking and camping await in the Crocker Range National Park.