Six thousand years ago, human footprints were left in the volcanic mud along the shores of Lake Managua. Preserved over centuries, these footprints can be seen at The Museum of Acahualinca in Managua, the capital of Nicaragua. In addition to the footprints and impressive collections of pre-Colombian artifacts in the city's museums, Managua has much more to offer. The Tiscapa Lagoon Natural Reserve is a watery retreat within the city, with bars, shops, ziplines, and a canopy ride with views of downtown.

This beautiful fishing village is a Nicaraguan gem, a magnet for surfers and sunbathers. At night, the beach still pulses with activity, thanks to a few popular beachfront bars and nightclubs. Surf clubs abound—catch a wave with an expert instructor if you’re a hang-ten rookie, trying to hang with the surfer big boys.

Columbia is South Carolina's capital and home to the University of South Carolina. Along its wide avenues are historic sites ranging from an antebellum mansion to the former home of a slave who bought her freedom, plus museums, galleries, music venues, theatres and shops. Columbia's three rivers, lake, canal, national park and several city parks offer opportunities for recreation and relaxation. Child-friendly destinations include a zoo and the largest children's museum in the south.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."