Home to two of America's most prestigious universities, Cambridge exudes a certain intellectual quirkiness. A mix of historical haunts, student hang-outs, alternative art and culture venues, vintage clothing shops, bookstores and ethnic restaurants, the city is, well, really cool. Although it is located just across the Charles River from Boston, Cambridge has a distinct vibe that is noticeable immediately. Start at Harvard Square, a hub of activity and mishmash of trendy stores, outdoor cafes and colorful local characters. Pick up a walking tour map at the visitors information booth in the centre of the Square. The route will take you past many important landmarks including the Mount Auburn Cemetery, Tory Row and the Longfellow National Historic Site. Harvard University offers student-led tours through the illustrious buildings and monuments of its sprawling campus. Art and architecture buffs should meander around the M.I.T campus, which includes outdoor sculptures by masters such as Picasso and 20th-century buildings designed by modern greats like Eero Saarinen and I. M. Pei. Along the way, browse through bookstores, stop to watch street performers and grab a coffee at an outdoor café to take in all this captivating city has to offer.

Only 21 miles from RDM airport, Bend is a natural playground for families and adventure travellers. Hiking and fishing along the Deschutes river, mountain biking and skiing at Mt. Bachelor are among the favourite activities. Enjoy award-winning restaurants or one of the nearly 30 breweries and pubs. Sunny weather compliments the many world class festivals and concerts. Bend is a great spot for family-friendly fun as well, from the High Desert Museum to ski areas with no fees for children under 12.

Within easy reach of both the Mediterranean and the Spanish borders, Perpignan blurs the line between French and Catalan cultures. The meandering, palm-dotted Old Town is anchored by a rust-coloured, Romanesque palace—a relic from when the city ruled the Kingdom of Mallorca.