The cultural hub of Malaysia, Kuala Lumpur is visually defined by the iconic Petronas Twin Towers, which, at 88 stories high, are the tallest twin buildings in the world and a vision of modern architecture. On the flip side, the Sri Mahamariamman is the oldest Hindu temple in Malaysia, its façade a colorful totem pole of iconography. Shopping at the Central Market is a joyful experience that involves haggling, handicrafts, and happiness.

Singapore is known as a bustling metropolis that also happens to be one of the cleanest and safest cities of its size in the world. (Just make sure you heed the local laws—something like spitting in the street might merely be considered rude in your hometown, but here, it carries a severe penalty.) You'll find historic sites like the Thian Hock Keng temple, superlative shopping (including gargantuan malls) and numerous beaches.

Kota Kinabalu on the island of Borneo is the bustling gateway to acclaimed Kinabalu National Park. The park's high point is 13,400-foot Mount Kinabula, Malaysia's tallest peak, a mecca for climbers. Ninety miles away, thrilling jungle trekking and camping await in the Crocker Range National Park.

Hong Kong's a great city for an adventurous eater. Stop at a street vendor for fish balls on a stick or stinky tofu. Bakeries offer wife cake, pineapple buns and egg tarts. Or opt for as much dim sum as you can eat. If you're tired of local and regional Chinese specialties, check out upscale offerings from some of the world's top chefs, like Joel Robouchon and Alain Ducasse.

From modern skyscrapers and neon lights to Buddhist temples, palaces and pagodas, Seoul is a fascinating mix of old and new. A hub of business, culture and finance both within South Korea and internationally, Seoul houses the headquarters for some of the world's largest corporations. It also has one of the world's best subway systems – the easiest way to get around in this densely populated area. For the best view of the city, go to the tower on Namsan, one of the mountains that encircle the city.

Lovely, laid-back Melbourne has something for everyone: family fare, local and international art, haute boutiques, multicultural dining, Australian and Aboriginal history, spectator sports, and pulsing, swanky nightlife. Cruise on the free City Circle Tram loop to check out unique attractions like the Royal Botanical Gardens and the Healesville Sanctuary, which buzzes with local animal species.