With a rich pre-Colombian history, Ecuador's capital was founded on the ruins of an Incan city but offers everything a modern traveller might need. It remains the least-altered historic centre in Latin America and has been designated a UNESCO World Heritage Site. Quito’s important sites include baroque gems like San Francisco and Santo Domingo monasteries, as well as La Compañía church and college. This huge city sprawls across a breathtaking Andean valley surrounded by volcanic peaks.

With an average of 320 days of Florida sunshine each year – and 27 miles of sugar-white sands bordering the clear, emerald green waters where the Gulf of Mexico and St. Andrew Bay converge – Panama City Beach is a favourite of travellers seeking an affordable beach holiday with year round offerings. The region also features exciting on- and off-shore attractions, including St. Andrews Park and Pier Park, that offer something special to adrenaline-seekers, eco-tourists, families and couples alike.

Wilmington is a vibrant riverfront city and the most accessible coastal area in the state. The pedestrian-friendly Riverwalk winds along the Cape Fear River, connecting many of the city’s shops, cafés, and nightlife with waterfront hotels, parks and the Port City Marina. Annual festivals, such as Riverfest, Wilmington Beer Week and the world-famous North Carolina Azalea Festival, attract crowds year-round. Three nearby island beaches offer even more dining, attractions and water sports.

You've got to walk the Freedom Trail the first time you visit Boston. That's just a given. Make sure you step off the line on the pavement, though, and explore some of Boston's fine museums (try the Gardner—art masterpieces displayed in their collector's mansion) and old neighbourhoods (like the North End, where you can get the best cannoli this side of Italy). You can't claim to have experienced real Boston culture, though, unless you've watched a Red Sox game from the bleachers.

Montreal, c’est si bon! This French-speaking city is considered the cultural capital of Canada, and is a cosmopolitan celebration of Québécois style. A horse-drawn carriage ride around the cobblestone streets and grand buildings of Vieux-Montréal will give you a taste of European flavour. The Basilique Notre-Dame is a confection of stained glass, and the Plateau Mont-Royal district will delight you with its quaint boutiques and cafés. Dig in to a massive plate of poutine to fuel up for a tour of the epic Olympic Park.

For a weekend of fun and relaxation, you don't have far to go. North Dakota's largest city gained a certain measure of modern fame with its 1996 film namesake. But Fargo is more than a city of friendly folks and flat accents. Local museums will please art lovers, children and baseball enthusiasts. After a family visit to the Red River Zoo, parents can unwind at local area lounges, many of which offer casino gaming. In Fargo's sister city of Moorhead, Minnesota, The Heritage Hjemkomst Interpretive Centre has replicas of a Viking ship and a Norwegian Stave church. Back in Fargo, Bonanzaville USA gives modern visitors a taste of pioneer life.

Everything about Santa Monica sizzles, from hundreds of funky shops and restaurants to more than three miles of white sandy beach, to the multitude of celebrities zipping into the local airport and out on Montana Avenue. The subject of popular songs, movies and television shows ("Baywatch" was one of many filmed here), the city has a vibe like no other. Hollywood haute couture meets surfer chic meets hippie casual, and somehow it all works. A word of advice: ditch the car and walk everywhere. Santa Monica is small and prides itself on being pedestrian- and environmentally friendly. You won't need wheels at the auto-free Third Street Promenade, a stroller's paradise known for its multitude of cinemas, restaurants and street performers. Or at the famous and historic Santa Monica Pier, home to tempting smells from fast-food stalls and the solar-powered, nine-storey high Ferris wheel that has long been a symbol of the city. If your feet start to fail, hop on the electrically powered Tide Shuttle, a bus service that runs along the beach offering great views plus a ride to the artsy Bergamot Station and the Santa Monica Museum of Art, or your next spirited Santa Monica destination.