Vilnius, the capital of Lithuania, contains one of the largest surviving medieval quarters in Europe. Included on the UNESCO World Heritage List, Old Town contains almost two thousand medieval, gothic, renaissance, and baroque buildings, all centered on the neo-classical cathedral and town hall. Other popular attractions include the KGB Museum, located in a former Soviet prison, and the 13th century Higher Castle, which affords a glorious view of the city center.

Sprawling along the edge of the Thermaic Gulf, Thessaloniki is a seaside showcase of Greek history from ancient Roman and Byzantine ruins to the modern high-rises lining its beaches. Plus, after sundown, Greece’s cultural capital hums with some of the best nightlife options in the Aegean.

Come play in El Gouna where the turquoise Red Sea sparkles. With resorts, spas and an 18-hole golf course, El Gouna lets you unwind under the sun. Book an excursion by land or sea—quad bikes are a popular way for the adventurous to see the desert. By night, trendy bars and the open-air disco welcome you to stay up late. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)