Punta del Este is known as the St. Tropez of Uruguay, thanks to its beautiful beaches, upscale resorts and swanky nightclubs. The Vegas-style Conrad Casino adds to the lively entertainment scene. For a break from surf and sand, saddle up with a local gaucho and ride horseback through the wild plains surrounding the city.

With nine bays and 36 beaches, Huatulco is ideal for anyone who loves the sun. It's not an overdeveloped resort town, but the hotels are comfortable—even luxurious. Ecotourism is gaining in popularity, so take a break from sunbathing and try river rafting or a hike through the jungle.

Miles of white sand and romantic island resorts beckon from the hem of the Palmetto State. Families gravitate to Myrtle Beach and the 60- mile span of Grand Strand, where over 100 championship golf courses, tennis courts and nightclubs await. Charleston's hundreds of heritage buildings and irresistible charm are part of its allure. Beach resorts at Kiawah Island, Seabrook and Edisto Island make for romantic getaways. Marshes, moss-bearded palms and oak groves create a haunting atmosphere in the Lowcountry.

Nestled in the fertile Susquehanna Valley, Harrisburg has played a pivotal role in the shaping of American history, both as a major link in rail and water transportation and as the setting of major Civil War battles. Having bounced back from economic distress in the 1980s, the city is now a vibrant hub of family activities, from cruises along the Susquehanna to arcades and athletics on City Island. The annual Pennsylvania Farm Show is the largest indoor agriculture exposition in the U.S.

The Berkshires are home to an impressive collection of cultural and historic sights. Get your fill of music, art and theatre at Tanglewood, the Boston Symphony's summer home, MASS MoCA, the country's largest contemporary art centre, the Norman Rockwell Museum and the Williamstown Theatre Festival. Recreational opportunities also abound, including snowshoeing, snowboarding, skiing, rafting, kayaking, fishing and golf. The Berkshires are an easy drive, just two and a half hours from Boston and New York.

Home to a well-preserved old town, modern architecture, and a UNESCO-listed carnival, Tenerife's capital easily competes with its mainland sisters as a Spanish cultural destination. The port city is a major Canary Islands hub, with balmy beaches, nature reserves, and cosmopolitan nightlife.