I live in Santa Ana but am not familiar with this hotel, however, I do know that it can take between 20 minutes and one hour to get to the airport from here, depending on traffic along Lindora towards Belin.
There are many closer options.
At that time of night there should not be much traffic, you will probably be in Santa Ana in 15 to 20 minutes.
Where are you heading the next day?
If you are going to the Central Pacific area, it would be a great place first night! Very easy access to the highway.
and...Santa Ana is great!
Depending on where you are going next, there are better options for you near the airport. I really like the Adventure Inn.
We are heading out to Guanacaste in the morning
Adventure Inn is about 8 minutes away.
Yes, very easy to find and a nice place.
Although Hotel Luisiana looks great, I think Adventure Inn is a better choice for you.
One other thing, I would, if I were you, not pick up the car late that night on your arrival unless you feel you are really going to need it at night. You can just get a cab to the hotel (Adventure Inn is quite close to the airport) and then, next more, after a good night rest, pick up your car in the early morning. Most of the rental car companies will deliver your car at the hotel withouth any extra cost. Do not pay for a day of car that you are not going to need or use that much. have you already decided who to rent the car from? If you have, ask them if they will deliver the car at Adventure Inn, I am pretty sure they will.
Also Hampton Inn ...just 4 minutes from SJO...good hotel...and most rent a cars are just minutes away...a lot better than Adventure Inn!
one question: what time are you arriving and what are your plans in guanacaste?