Hopefully, some good local recommendations will come along. In the meantime...
I am a BBQ addict, and there are a couple good websites I use when I'm traveling around SC. I particularly like the 100-mile BBQ list, which is part of the SC BBQ Association website. If you find somewhere good, let me know!
Hudson's Smokehouse (on Sunset Blvd). Good BBQ, fast service, very generous portion sizes!
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