The big question facing is and many first time visitors is do I do a land or sea based vacation. My brother took a cruise pre-pandemic and loved it but would have liked to spend more time off the boat so we opted for a land based vacation and Santa Cruz Island, specifically Puerto Ayora, was where we stayed. From here , we spent one day on the island seeing the Darwin Research Center (walking distance from where we stayed), the giant tortoises at El Chato and the collapse Craters at Los Gemelos. The other three days were day cruises on luxury yachts to nearby islands. We really enjoyed our vacation and I would definitely recommend making Santa Cruz your base during your stay.